← Biochemistry (BIOCHEM)

Hardest courses in Biochemistry

Plan ahead for courses where students have earned lower grades.

Lowest historical GPA first. At least 100 letter grades over the five years through the selected term. Grades reflect past outcomes, not workload or a guaranteed result.

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17 courses

Historical grades cover up to five years through the selected term. Only courses with at least 100 letter grades are ranked.

GENERAL BIOCHEMISTRY II covers biosynthesis, signal transduction, nucleic acid metabolism, and protein synthesis.

Offering recorded · Fall 2026

The course requires significant memorization of metabolic pathways and reactions. Students report that dense content and difficult exams necessitate creating condensed study tables and dedicating ample time to preparation to finish exams on time.

historical GPA · grades

Spring 2022–Spring 2026

Covers the chemistry of biological materials, intermediary metabolism, and protein structure.

Offering recorded · Fall 2026

Historical reviews of Aaron Hoskins, Michael Cox, Timothy Grant: Students must read the textbook to succeed, as lectures alone are insufficient. Exams cover vast amounts of information, including small details, and can be challenging with easy point loss despite preparation.

historical GPA · grades

Spring 2022–Spring 2026

Lectures on nutritional biochemistry and metabolism, emphasizing biochemical and physiological fundamentals of nutrition.

Offering recorded · Fall 2026

historical GPA · grades

Spring 2022–Spring 2026

Covers the chemistry, nutrition, and metabolism of biological systems.

Offering recorded · Fall 2026

The course involves four noncumulative exams requiring significant memorization of cycles and pathways. Some reviewers find their specific sections dense and difficult, particularly those focusing on catabolism, while others note that exams are fair if students study practice problems.

historical GPA · grades

Spring 2022–Spring 2026

Covers the molecular basis of bacterial physiology and genetics, focusing on mechanisms like transcription, translation, and gene regulation.

Offering recorded · Fall 2026

Historical reviews of Katrina Forest: Exams are open book but very hard, forcing students to understand material inside out and problem-solve on the fly.

historical GPA · grades

Fall 2022–Fall 2025

BIOCHEMICAL METHODS introduces modern biochemical laboratory techniques and current literature through lab experiments and student seminars.

Offering recorded · Fall 2026

Historical reviews of Lynne Prost: Reviewers report that lectures move too fast to take notes and lab grading criteria are unclear. The lab work is described as tedious and repetitive for those with prior experience, while exams are considered easy.

historical GPA · grades

Spring 2022–Spring 2026

Covers genetics and genomics applied to plant development, including breeding systems, linkage, and genome structure.

Offering recorded · Fall 2026

historical GPA · grades

Fall 2022–Fall 2025

CHEMICAL BIOLOGY covers the chemistry and biology of macromolecules and applies organic chemistry to cell biology and biomedicine.

Offering recorded · Fall 2026

Historical reviews of Andrew Buller: The course requires reading papers and completing assignments, characterized as heavy biology with a high difficulty rating.

historical GPA · grades

Fall 2022–Fall 2025

BIOCHEM 100 introduces students to the biochemistry discipline, department, faculty research, university resources, and career paths.

Offering recorded · Fall 2026

historical GPA · grades

Spring 2022–Spring 2026

A seminar for CIBM program trainees discussing current research in computation and informatics in biology and medicine.

Offering recorded · Fall 2026

historical GPA · grades

Spring 2022–Spring 2026

A graduate seminar focusing on presentations and discussions of recent chemical biology research.

Offering recorded · Fall 2026

historical GPA · grades

Spring 2022–Fall 2025

BIOCHEM 104 introduces molecular life and evolution, exploring current biotechnology and genetic topics to foster scientific literacy.

Offering recorded · Fall 2026

Homework requires approximately 30 minutes per week, indicating a manageable workload.

historical GPA · grades

Spring 2022–Spring 2026

This graduate course covers various selected topics in contemporary macromolecular and biophysical chemistry.

Offering recorded · Fall 2026

The course difficulty is rated as moderate, with a rating of 3 out of 5.

historical GPA · grades

Spring 2022–Spring 2026

BIOCHEM 729 covers specialized subjects of current interest in biochemistry.

Offering recorded · Fall 2026

historical GPA · grades

Spring 2022–Spring 2026

BIOCHEM 299 is an independent study course where students conduct research under the direct guidance of a Biochemistry faculty member.

Offering recorded · Fall 2026

historical GPA · grades

Spring 2022–Spring 2026

A seminar for Biotechnology Training Program trainees to present their research for critical review by an audience.

Offering recorded · Fall 2026

historical GPA · grades

Spring 2022–Spring 2026

BIOCHEM 699 offers academic credit for research, library, or laboratory work conducted under faculty guidance.

Offering recorded · Fall 2026

Aaron Hoskins receives a single negative review citing poor communication and judgment, which the reviewer claims negatively impacts student career prospects.

historical GPA · grades

Spring 2022–Spring 2026