The course requires significant memorization of metabolic pathways and reactions. Students report that dense content and difficult exams necessitate creating condensed study tables and dedicating ample time to preparation to finish exams on time.
“Used by” includes alternatives; linked courses may have other requirements. This is a best-effort interpretation; check the catalog requirements above.
Raw average: 5.00/5 from 1 quality ratings. The adjusted rating blends this with the UW review average (3.66/5), weighted as 20 additional ratings. Smaller samples stay closer to that average. Each captured review is counted once in the prior; this does not correct who chooses to leave a review.
RMP profile ↗ · All captured review dates; profile matched by name.
Robert Kirchdoerfer is described as kind, accessible during office hours, and knowledgeable about his lecture unit. Reviewers note that his lectures are well-organized and his test preparation materials accurately reflect the actual exam content.
Recent recorded grades — Fall 2024: 2.78 GPA, 39.0% A/AB (n=41 letter grades); Spring 2025: 2.73 GPA, 32.7% A/AB (n=98 letter grades); Fall 2025: 2.91 GPA, 32.8% A/AB (n=64 letter grades). Includes jointly taught sections.
Raw average: 3.83/5 from 6 quality ratings. The adjusted rating blends this with the UW review average (3.66/5), weighted as 20 additional ratings. Smaller samples stay closer to that average. Each captured review is counted once in the prior; this does not correct who chooses to leave a review.
RMP profile ↗ · All captured review dates; profile matched by name.
Judith Simcox is praised for her passion, clear explanations, and accessibility, with students noting her helpful anecdotes and fair testing. Conversely, some reviewers found her lectures confusing and exams difficult, while others criticized her exams as unfair and practice tests as unrepresentative.
Recent recorded grades — Fall 2024: 2.78 GPA, 39.0% A/AB (n=41 letter grades); Spring 2025: 2.73 GPA, 32.7% A/AB (n=98 letter grades); Fall 2025: 2.91 GPA, 32.8% A/AB (n=64 letter grades). Includes jointly taught sections.
Historical instructors & teaching patterns
Historical reviews of David Pagliarini: David Pagliarini is consistently praised for clear, concise lectures and fair exams. Reviewers highlight his ability to make material applicable and his provision of study guides, though some note he only teaches a fraction of the course.
DAVID PAGLIARINI is recorded teaching in Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, Spring 2019. Recorded history may be incomplete and does not establish a future schedule.
JAMES NTAMBI is recorded teaching in Spring 2017. Recorded history may be incomplete and does not establish a future schedule.
JUDITH SIMCOX is recorded teaching in Spring 2020, Spring 2022, Fall 2022, Spring 2023, Fall 2023, Spring 2024, Fall 2024, Spring 2025, Fall 2025. Recorded history may be incomplete and does not establish a future schedule.
ROBERT KIRCHDOERFER is recorded teaching in Spring 2022, Fall 2022, Spring 2023, Fall 2023, Spring 2024, Fall 2024, Spring 2025, Fall 2025. Recorded history may be incomplete and does not establish a future schedule.
SEBASTIAN BEDNAREK is recorded teaching in Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, Spring 2018, Spring 2019, Spring 2020, Spring 2022, Fall 2022, Spring 2023, Fall 2023, Spring 2024, Fall 2024, Spring 2025, Spring 2026. Recorded history may be incomplete and does not establish a future schedule.
Recorded history may be incomplete and does not establish a future
schedule.
Calendar & sections
Fall 2026
Schedule loads here as you scroll.
Section
Mode
Enrolled / capacity
Waitlist
LEC 001
Classroom Instruction
42 / 140
0
Times are Central. Select a meeting for details; export includes recorded dates for the selected sections. Enrollment reflects scan time.
Most reviewers praise current instructors Judith Simcox and Robert Kirchdoerfer for their passion, organization, and accessibility, noting that exams align well with practice materials. However, some students report that Simcox’s exams are unfairly difficult and confusing, creating a polarized experience.
Recent recorded grades — Spring 2025: 2.73 GPA, 32.7% A/AB (n=98 letter grades); Fall 2025: 2.91 GPA, 32.8% A/AB (n=64 letter grades); Spring 2026: 2.98 GPA, 39.1% A/AB (n=87 letter grades).
difficulty & workload
The course requires significant memorization of metabolic pathways and reactions. Students report that dense content and difficult exams necessitate creating condensed study tables and dedicating ample time to preparation to finish exams on time.
Students find Simcox and Kirchdoerfer accessible outside of class, with Kirchdoerfer providing clear test prep and Simcox offering helpful anecdotes. Simcox also points out clearly what to know for exams, while reviewers appreciate her passion and engagement.
Topics
Biosynthesis of biological molecules
Signal transduction mechanisms
Chemistry and metabolism of nucleic acids
Protein synthesis
Molecular and cellular biology
Skills
Understanding biosynthesis, signal transduction, nucleic acid chemistry, and protein synthesis.
Grades
Latest available · Spring 2026— not enough history to project Fall 2026.
average GPA
A / AB grades
letter grades
Instructor
Grade distribution · % of letter grades
A26.4%26.4%
AB12.6%12.6%
B33.3%33.3%
BC6.9%6.9%
C13.8%13.8%
D3.4%3.4%
F3.4%3.4%
Grades over time
Through Spring 2026
More grade details Grade mix, volume & source data
Where this course fits relative to
Latest available grades · Spring 2026 · all course levels
2.982.98GPA
Higher than 44% of other courses
in this group.
Course GPAs · red marks this course’s range
8787letter grades
More recorded grades than 6262% of other courses in this group.
Typical course in this group: 66.066.0 letter grades.
About this comparison
1283 courses over the same term, each with at least 30
recorded letter grades. Cross-listed courses count once. GPA is not a measure
of difficulty or teaching quality. The typical course is the median by recorded
grade count; tied values are not counted as lower. Grade counts describe course scale, not unique students or typical section size.
Descriptions compare GPA with this group’s average: at least 0.20 higher or lower; otherwise close to average. Section size uses median recorded enrollment: small up to 30, mid-sized 31–99, large 100+. Lectures and discussion/lab sections are described separately.
Sources & history
UW–Madison
Catalog & offerings
Descriptions, prerequisites, and recorded course offerings.
Catalog observation history
Observations at scan time; dates do not imply when a catalog change took effect.