QUANTITATIVE SYSTEMS BIOLOGY AND DISEASE

BME/CBE 782

Literature survey of mathematical models in biology at the molecular and cellular levels; application of chemical kinetics and thermodynamics to biological systems; comparison of deterministic and stochastic strategies.

BME 780

Focuses on understanding the key methods and principles of quantitative biology through a close reading of the primary literature. Topics covered will include deterministic and stochastic methods for modeling cellular systems, techniques in systems and synthetic biology, image processing tools and image analysis for biology, data-driven network models, genomic approaches, single-molecule approaches, and key computational biology tools. This course is intended for graduate students from a variety of backgrounds who are interested in pursuing quantitative biology during their graduate studies.

BMI/COMPSCI 775

Introduces networks as a powerful representation in many real-world domains including biology and biomedicine. Encompasses theory and applications of networks, also referred to as graphs, to study complex systems such as living organisms. Surveys the current literature on computational, graph-theoretic approaches that use network algorithms for biological modeling, analysis, interpretation, and discovery. Enables hands-on experience in network biology by implementing computational projects.

BIOCHEM/BMI/BMOLCHEM/MATH 609

Provides a rigorous foundation for mathematical modeling of biological systems. Mathematical techniques include dynamical systems and differential equations. Applications to biological pathways, including understanding of bistability within chemical reaction systems, are emphasized.

BME 556

Introduction to the experimental and mathematical modeling techniques used in systems biology through lectures and critical analyses of relevant publications with a primary focus on gene/protein networks and mammalian systems.