NEUROGENETICS

GENETICS/NEURODPT 650

Functional genomics methods (RNA-seq, ATAC-seq, Hi-C, ChIP-seq, Tag, etc.) and their applications in the study of molecular and cellular mechanisms governing brain development, evolution, and neurodevelopmental and neuropsychiatric disorders. Overview of relevant aspects of Genetics and Neuroscience, including genomic approaches for gene discovery for human disorders and key properties of brain cells and circuit development. Bioinformatic approaches for analyzing genome-scale data sets. Critical consideration of experimental design and analysis strategies through reading and discussion of primary research literature and the development of an original research proposal. Emphasis will be placed upon how to effectively communicate science (written and oral).

GENETICS/MDGENET 565

Principles, problems, and methods of modern human genetics. Focuses on how researchers discover the genetics of diseases and how those discoveries are used to improve clinical practice. Surveys aspects of (i) the molecular function of the human genome, (ii) the basic principles of human genetics including statistical genetics, quantitative genetics, and genomic variation in human populations, (iii) the genetics of rare disorders and common diseases, and genomic analysis approaches, including genome-wide association studies and sequencing, and (iv) how genetics are used in medicine and discussions covering ethical considerations of human genomic data.

GENETICS 627

Advanced genetics course focusing on genetic mechanisms of animal embryonic development, with particular emphasis on central molecular circuitries that control development and genetic analytical tools used to reveal them. Address topics including maternal and epigenetic inheritance, the egg-to-embryo transition, pattern formation, organogenesis, coordination of cellular and molecular mechanisms, and animal models of human congenital disorders.

GENETICS/MDGENET 707

A research-level analysis of the current status of the investigation of processes controlling differential gene activity and cellular behavior. The major emphasis is genetic. In successive years, the focus moves from the gene to the cell to the organism.

NEUROL 735

Overview of the major categories of human neurological and opthalmological disease to fundamental topics in neurobiology.