MODELING NEURODEVELOPMENTAL DISEASE

ONCOLOGY 745

Provides a background in the use of animals in the study of human disease and hands-on exposure to common techniques such as tissue collection and processing, surgeries, imaging, and other manipulations. Lectures by basic scientists and clinicians will provide background about each of the organ systems or diseases and the ethics of animal research. Prior to start of course, completion of online animal safety training. Instructions will be provided after enrollment.

NEURODPT/ZOOLOGY 765

Analysis of neural development with emphasis on experimental approaches. Combination of lectures and discussions of primary literature. Topics include neural induction, patterning, mechanisms of axon guidance, neural crest cell migration and differentiation, cortical development, and synapse formation and elimination.

GENETICS 627

Advanced genetics course focusing on genetic mechanisms of animal embryonic development, with particular emphasis on central molecular circuitries that control development and genetic analytical tools used to reveal them. Address topics including maternal and epigenetic inheritance, the egg-to-embryo transition, pattern formation, organogenesis, coordination of cellular and molecular mechanisms, and animal models of human congenital disorders.

ZOOLOGY 444

Provides an advanced understanding of cell biology as it relates to the nervous system. Covers the neuronal cytoskeleton, molecular motors and their cargos, the secretory system and how it functions in neurons, formation and maintenance of pre- and post-synaptic structures, neuronal organelles and their functions. Discussion of what is known about the disruptions to cell biology of neurons that contributes to neurodevelopmental and neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Amyotrophic Lateral Sclerosis, Charcot Marie Tooth Disease, Spinal Muscular Atrophy, and others.

NEUROL 735

Overview of the major categories of human neurological and opthalmological disease to fundamental topics in neurobiology.