THE MOLECULAR BASIS OF HEMATOLOGIC MALIGNANCIES

GENETICS/MDGENET 662

Focuses on the genetic basis by which cancer manifests. Provides a comprehensive overview of how cancer is generated as a result of abnormalities at the DNA level, paying special attention to oncogenes, tumor suppressors, DNA mutations, DNA repair mechanisms, chromosomal instability, and tumor heterogeneity. Stresses the role of the immune system in combating cancer, the phenomenon of cancer resistance, anti-tumor strategies, and epigenetic influences on tumorigenesis. Highlights connections between course material and clinical relevance.

MEDICINE 935

Exposure to patients in outpatient hematology and oncology clinics and on the inpatient consultation service. Oncology-focused rotation topics include staging and prognosis of different malignancies, basics of chemotherapy classes, and indications for chemotherapy. Hematology content includes the diagnostic approach to clotting disorders, anemia, and/or abnormal blood counts. Different chemotherapy treatments for hematologic malignancy may be included in this course. Independent reading is expected; didactic conferences are site-specific.

PATH 750

Emphasizes current understanding of molecular and cellular mechanisms. Wherever possible, human diseases are used to illustrate the outcome at the organismal level of defects in these mechanisms. Focuses on different cell types and how cells function. We also discuss how cells talk to themselves and each other. Topics include mechanisms of cell survival and division. Provides an overview of a broad set of cell biology topics to demonstrate the breadth and diversity of cellular functions.

PATH 752

The emphasis is on our current understanding of molecular and cellular mechanisms. Wherever possible, human diseases are used to illustrate the outcome at the organismal level of defects in these mechanisms. Discussions focus on immunology and cancer biology. Topics include mechanisms of cell survival, cell division, signal transduction, gene expression, vesicular transport, autophagy and cell death. Explore a broad set of cell biology topics, in greater detail such that they will have a better understanding of the breadth and diversity of cellular functions by the end of the semester. Learn how to critically evaluate the literature and the rigor of research.

PATH 809

Focuses on molecular mechanisms of diseases. Course will focus on four modules: Neuroscience, cancer biology, growth factor/matrix biology, and immunology. Course will consist of a one hour lecture and a one hour group discussion.