Spring 2027

Neuroscience of Psychedelics

Explores neural mechanisms of serotonergic psychedelics' therapeutic effects, linking serotonin receptor actions to cellular, network, and behavioral outcomes within models of perception, cognition, and consciousness.

offering recorded3 credits
Recorded instructors · Spring 2027 Matthew Banks

Summary

What you’ll be able to do

  • Describe experimental techniques and measurements used to probe changes in neuronal activity and connectivity and identify the major limitations of each method and propose approaches to overcome those limitations

  • Describe experimental techniques and measurements used to probe changes in neuronal activity and connectivity

  • Identify the major known classical psychedelic agents in terms of their chemical structure, targets (receptors, cells, brain areas) in the brain, duration of action, and suitability for administration in a clinical setting

  • Identify the major known classical psychedelic agents in terms of their chemical structure, targets (receptors, cells, brain areas) in the brain, duration of action, and suitability for administration in a clinical setting and also summarize the signaling pathways underlying cellular actions of psychedelic agents.

  • Demonstrate knowledge of the cell types and brain areas most likely to mediate distinct behavioral effects of psychedelics, and of the experimental support for these hypotheses.

  • Demonstrate knowledge of the cell types and brain areas most likely to mediate distinct behavioral effects of psychedelics, and of the experimental support for these hypotheses, and also demonstrate ability to identify gaps in experimental support for these hypotheses and to design experiments to fill those gaps

  • Identify and summarize the major behavioral assays of the psychedelic experience and of psychiatric disorders (e.g. depression scales).

  • Identify and summarize the major behavioral assays of the psychedelic experience and of psychiatric disorders (e.g. depression scales), and also identify and summarize the shortcomings of the major behavioral assays of the psychedelic experience and of psychiatric disorders (e.g. depression scales), and demonstrate ability to propose revisions of those scales to address those shortcomings.

  • Identify and summarize clinical applications of psychedelics, and the theories and factors contributing to their therapeutic benefit

  • Identify and summarize clinical applications of psychedelics, and the theories and factors contributing to their therapeutic benefit, and also demonstrate knowledge of the experimental support for each theory and factor.

Source: UW Guide

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Prerequisites

Course map

PSYCH/​ZOOLOGY 523,PSYCH/​NEURODPT/​NTP 611, PHARMACY 770,PHM SCI 770, or graduate/professional standing. Not open to students with credit for NTP 632.

PHMSCI 632

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Professors

Spring 2027
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Calendar & sections

Spring 2027

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SectionModeEnrolled / capacityWaitlist
LEC 001Classroom Instruction0 / 00
LEC 002Online Only0 / 450

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Student experience

the class

Explore the neural mechanisms of the therapeutic effects of serotonergic psychedelics, focusing on how the actions of these drugs at specific serotonin receptor subtypes might couple to cellular, network, and behavioral effects, and how these mechanisms intersect with current models of the neural basis of perception, cognition, and consciousness. Not open to students with credit for PHARMACY 632 prior to fall 2026.

difficulty & workload

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Topics

  • Serotonin receptor subtypes and their coupling to cellular, network, and behavioral effects
  • Intersection of psychedelic mechanisms with models of perception, cognition, and consciousness
  • Clinical applications of psychedelics and theories of their therapeutic benefit

Skills

  • Describe experimental techniques for probing neuronal activity and connectivity, including their limitations and potential improvements
  • Identify gaps in experimental support for psychedelic behavioral effects and design experiments to address them
  • Evaluate behavioral assays for psychedelic experience and psychiatric disorders, and propose revisions to address their shortcomings

Grades

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Sources & history

UW–Madison

Catalog & offerings

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Selected offering source records
PHMSCI 632 · Spring 2027

Neuroscience of Psychedelics

Recorded 2026-10-14
Raw records
[
  {
    "run_id": "20261014T203208-0851c9a1",
    "semester": "1274",
    "observed_at": "2026-10-14 17:50:09.728220+00:00",
    "offering_id": "1274:718:026623",
    "course_id": "PHMSCI 632",
    "course_uid": "course_86d157742bccb7503e888329",
    "term_id": "1274",
    "source_course_id": "026623",
    "source_subject_id": "718",
    "title": "Neuroscience of Psychedelics",
    "credits_min": 3,
    "credits_max": 3,
    "typically_offered": "Not Applicable"
  }
]
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Model outputs & technical records
Qwen/Qwen3.8-27B
LLM outputs across runs
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Model & dataset provenance
{
  "model": "Qwen/Qwen3.8-27B",
  "model_revision": "1d4bf0f2ff6012fd82039f2fa52739d0dd7c60c0",
  "task_version": "17",
  "output_id": "3f14fc8b3057e86d68d30fabe29bf37c89d3b9d9f51e4dc25dd5f8cdcba68b45",
  "requirements_status": "needs_review",
  "dataset_revision": "fc1811fa52e581ea57a35c0cf3343f8740a8ffbf",
  "observed_at": "2026-10-14 17:50:09.728220+00:00"
}