The Molecular Basis of Hematologic Malignancies
Recorded 2026-10-14 Spring 2027
The Molecular Basis of Hematologic Malignancies
This course examines molecular mechanisms of hematologic malignancies and how laboratory assays guide diagnosis and therapy.
offering recorded2 credits
Recorded instructors · Spring 2027 No instructors listed
Summary
What you’ll be able to do
Describe basic processes underlying normal hematopoiesis and lymphocyte development.
Apply basic principles, advantages, and limitations of the most common forms of ancillary testing in hematopathology, including flow cytometry, cytogenetics/FISH, and select molecular assays.
Explain types of molecular abnormalities observed in neoplasia and how these abnormalities contribute to neoplastic growth via various cellular pathways.
Describe the molecular basis, pathophysiology, and laboratory evaluation of known or suspected myeloid malignancies (including MDS, MPN, MDS/MPN, AML, and systemic mastocytosis)
Describe the molecular basis and pathophysiology of clonal hematopoiesis of indeterminate potential (CHIP) and clonal cytopenia of uncertain significance (CCUS), and understand how these entities may complicate the molecular evaluation of suspected myeloid malignancies.
Describe the molecular basis, pathophysiology, and laboratory testing of lymphoid malignancies, including lymphoblastic lymphomas/leukemias and B-cell and T-cell lymphomas.
Describe the role of precision medicine and the utility of current and evolving targeted therapies in hematolymphoid disorders.
Source: UW Guide
Grade history
↗ average GPA
00 letter grades
No recorded grade history.
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Prerequisites
Course mapMED SC-M 810, 811, 812, and 813
PATH 962
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Professors
Spring 2027No instructors recorded for this selection.
Historical instructors & teaching patterns
Recorded history may be incomplete and does not establish a future schedule.
Calendar & sections
Spring 2027Schedule loads here as you scroll.
| Section | Mode | Enrolled / capacity | Waitlist |
|---|---|---|---|
| LEC 004 | Classroom Instruction | 0 / 4 | 0 |
| LEC 007 | Classroom Instruction | 0 / 4 | 0 |
Times are Central. Select a meeting for details; export includes recorded dates for the selected sections. Enrollment reflects scan time.
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Student experience
the class
Understanding molecular mechanisms of hematologic disease, and developing a foundation in the principles of relevant molecular assays, is critical to providing appropriate patient care. Topics include bases of neoplastic disorders of the hematopoietic and lymphoid systems, how underlying molecular abnormalities contribute to the pathophysiology of these diseases, and the evolving spectrum of molecular and cytogenetic/FISH testing and other ancillary testing (such as flow cytometry), which are often utilized in the work-up of hematopoietic and lymphoid malignancies. Learn about strengths and weaknesses of these technologies, and how pathologists integrate results of molecular testing with the traditional histologic exam to produce accurate diagnoses and drive clinical decision making. Develop an understanding of how knowing the underlying molecular pathology of a hematopoietic or lymphoid malignancy can inform prognosis and guide therapy.
difficulty & workload
No workload feedback recorded.
Topics
- Neoplastic disorders of the hematopoietic and lymphoid systems.
- Molecular abnormalities that drive pathophysiology.
- Molecular, cytogenetic/FISH, and flow cytometry testing.
- Myeloid malignancies including MDS, MPN, MDS/MPN, AML, and systemic mastocytosis.
- Lymphoid malignancies and their laboratory evaluation.
- Precision medicine and targeted therapies in hematolymphoid disorders.
Skills
- Integrate molecular test results with histologic examination to support diagnosis.
- Apply principles, advantages, and limitations of hematopathology assays.
- Use molecular pathology findings to inform prognosis and therapy.
Grades
Instructor
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Sources & history
UW–Madison
Catalog & offerings
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Raw records
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"semester": "1274",
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"course_id": "PATH 962",
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"term_id": "1274",
"source_course_id": "025926",
"source_subject_id": "704",
"title": "The Molecular Basis of Hematologic Malignancies",
"credits_min": 2,
"credits_max": 2,
"typically_offered": "Not Applicable"
}
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View the dataset on Hugging Face Recorded 2026-10-14
Model outputs & technical records
Qwen/Qwen3.8-27B
LLM outputs across runs
Full model traces
Recorded model configuration, reasoning, and tool conversations.
Model & dataset provenance
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