Spring 2027

The Role of the Human Microbiome in Health and Disease

Examines the human microbiome's role in health and disease using next-generation sequencing and bioinformatics to study microbial associations with healthy and disease conditions.

offering recorded2 credits
Recorded instructors · Spring 2027 Andrew Hryckowian

Summary

What you’ll be able to do

  • Demonstrate a clear understanding of the current literature regarding the human microbiome and its role in health.

  • Compare and contrast current state-of-the art methodologies to study the human microbiome and further demonstrate the ability to apply this knowledge to critically assess clinical study outcomes involving microbiome data.

  • Describe and explain how basic bioinformatic pipelines are used to analyze and interpret microbiome data.

  • Apply learned ecological concepts to the analysis of a real human microbiome dataset generated by researchers at the UW-Madison.

  • Design a human microbiome study, clearly defining possible endpoints and inherent limitations.

Source: UW Guide

Grade history

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letter grades

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Prerequisites

Course map

MED SC-M 810, 811, 812, and 813

MM&I 902

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Professors

Spring 2027
Historical instructors & teaching patterns

ANDREW HRYCKOWIAN is recorded teaching in Spring 2023, Spring 2024, Spring 2025, Spring 2026. Recorded history may be incomplete and does not establish a future schedule.

Recorded history may be incomplete and does not establish a future schedule.

Calendar & sections

Spring 2027

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SectionModeEnrolled / capacityWaitlist
LEC 005Online Only0 / 50

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Student experience

the class

The human microbiome can profoundly influence the balance between health and disease. Advances in next-generation sequencing technology and bioinformatics enabled the detailed study of the trillions of microorganisms living in us and on us and their associations with both healthy and disease conditions. Current state of the art approaches to study the microbiome through examples of human diseases with a known microbiome component. Critically assess the microbiome literature and design clinical studies aiming to include the microbiome as a variable. Bioinformatics tools required to study complex microbial communities by reproducing published datasets from human patients and learn ecological concepts to interpret results in a clinically meaningful way.

difficulty & workload

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Topics

  • State-of-the-art approaches to studying the microbiome in human diseases with known microbiome components.
  • Next-generation sequencing technology and bioinformatics for studying microorganisms in and on humans.
  • Clinical study design incorporating the microbiome as a variable, including endpoints and limitations.

Skills

  • Critical assessment of microbiome literature and design of clinical studies including microbiome variables.
  • Use of bioinformatic pipelines to reproduce published datasets and analyze/interpret microbiome data.
  • Application of ecological concepts to interpret microbiome results in a clinically meaningful way.

Grades

Instructor

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Sources & history

UW–Madison

Catalog & offerings

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Catalog observation history

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Selected offering source records
MM&I 902 · Spring 2027

The Role of the Human Microbiome in Health and Disease

Recorded 2026-10-14
Raw records 
[
  {
    "run_id": "20261014T203208-0851c9a1",
    "semester": "1274",
    "observed_at": "2026-10-14 17:50:09.728220+00:00",
    "offering_id": "1274:620:025245",
    "course_id": "MM&I 902",
    "course_uid": "course_5e3270eb19056298b2dd4a60",
    "term_id": "1274",
    "source_course_id": "025245",
    "source_subject_id": "620",
    "title": "The Role of the Human Microbiome in Health and Disease",
    "credits_min": 2,
    "credits_max": 2,
    "typically_offered": "Not Applicable"
  }
]
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Dataset & model

Recorded 2026-10-14

View the dataset on Hugging Face
Model outputs & technical records
Qwen/Qwen3.8-27B
LLM outputs across runs
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Full model traces

Recorded model configuration, reasoning, and tool conversations.

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Model & dataset provenance 
{
  "model": "Qwen/Qwen3.8-27B",
  "model_revision": "1d4bf0f2ff6012fd82039f2fa52739d0dd7c60c0",
  "task_version": "17",
  "output_id": "06df162bf04d3c73ea28e48990688285911d0cc40c41161751fa70f734db992e",
  "requirements_status": "valid",
  "dataset_revision": "fc1811fa52e581ea57a35c0cf3343f8740a8ffbf",
  "observed_at": "2026-10-14 17:50:09.728220+00:00"
}