BIOPHOTONICS LABORATORY

BME 751

The study and use of light in the life sciences. Interactions of light with cells and tissue can be used for imaging, measurement, diagnosis, and therapy. Applications include optical imaging, endoscopy, microscopy, resolution enhancement, adaptive optics, Optical Coherence Tomography (OCT), quantitative phase microscopy, spectroscopy (fluorescence, elastic scattering), diffuse optical tomography, and computational modeling of light transport in tissue. Fundamental skills, concepts, and theory used for these applications include geometric optics, lens design, Fourier transforms, polarization, interference, coherence, and scattering theory. Particular emphasis will be placed on current literature and cutting edge instruments and methods.

BME/CHEM/MEDPHYS 750

Covers several aspects of state-of-the-art biological and biophysical imaging with an emphasis on instrumentation, beginning with an overview of geometrical optics and optical and fluorescence microscopy. The bulk of the course will focus on advanced imaging techniques including nonlinear optical processes (multi-photon excitation, second harmonic generation, and stimulated Raman processes) and emerging super-resolution methods. Special emphasis will be given to current imaging literature and experimental design. Knowledge of physics-based optics [such asPHYSICS 202] strongly recommended.

BME 604

Various special topics in biomedical imaging and optics.

CHEM 668

Focuses on the underlying principles and applications of spectroscopic and microscopy methods employed to solve biological problems at the atomic and molecular level. Techniques covered include electronic absorption and fluorescence spectroscopy, circular dichroism, light scattering, fluorescence microscopy, multidimensional nuclear magnetic resonance and electron spin resonance.

ECE 747

Optics/photonics at nanometer and micrometer length scales, including EM waves in dielectrics and metals, computational electromagnetics, waveguides and waveguide coupling, optical resonators, basic nanofabrication techniques, thin-film interference, surface-plasmon polaritons, localized surface-plasmon resonances, applications of plasmonics, super-resolution imaging, photonic crystals, composite materials and metamaterials, metasurfaces. Knowledge of Maxwell's equation and basic ray/wave optics, as would typically be obtained from junior-level or higher electromagnetics or optics courses [such asE C E 320orE C E 434], is strongly encouraged.